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Razoxane and Dexrazoxane - Two Multifunctional Agents - KURT HELLMANN - WALTER RHOMBERG

Razoxane and Dexrazoxane - Two Multifunctional Agents

Titre de l'éditeur : Razoxane and Dexrazoxane - Two Multifunctional Agents

KURT HELLMANN
WALTER RHOMBERG

 
275,82 $
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EN SAVOIR PLUS Résumé

Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer´s disease could be stabilized by one or both these drugs.

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Prix : 275,82 $
Catégorie :
Auteur :  KURT HELLMANN
WALTER RHOMBERG
Titre : Razoxane and Dexrazoxane - Two Multifunctional Agents
Date de parution : août 2010
Éditeur : LIVRES NUMÉRIQUES DIVERS
Sujet : NUL DIVERS
ISBN : 9789048191680 (9048191688)
Référence Renaud-Bray : 3062597
No de produit : 3062597
Droits numériques
Format : EPUB
Disponibilité : Canada, consultez la liste des pays autorisés.
Gestion des droits numériques : Adobe DRM
Entrepôt numérique : NUMILOG
Nombre d'appareils autorisés : 3
Nombre de copier/coller : 0
Impression : 0

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Razoxane and Dexrazoxane - Two Multifunctional Agents , HELLMANN , KURT*RHOMBERG , WALTER
© LIVRES NUMÉRIQUES DIVERS 2010