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LIVRES NUMÉRIQUES
Cancer Drug Delivery Systems Based on the Tumor Microenvironment - YASUHIRO MATSUMURA - DAVID TARIN

Cancer Drug Delivery Systems Based on the Tumor Microenvironment

Titre de l'éditeur : Cancer Drug Delivery Systems Based on the Tumor Microenvironment

YASUHIRO MATSUMURA
DAVID TARIN

 
202,21 $
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EN SAVOIR PLUS Résumé

This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.


Détails
Prix : 202,21 $
Catégorie :
Auteur :  YASUHIRO MATSUMURA
DAVID TARIN
Titre : Cancer Drug Delivery Systems Based on the Tumor Microenvironment
Date de parution : janvier 2020
Éditeur : LIVRES NUMÉRIQUES DIVERS
Sujet : NUL DIVERS
ISBN : 9784431568803 (4431568808)
Référence Renaud-Bray : 3058524
No de produit : 3058524
Droits numériques
Format : PDF
Disponibilité : Canada, consultez la liste des pays autorisés.
Gestion des droits numériques : Adobe DRM
Entrepôt numérique : NUMILOG
Nombre d'appareils autorisés : 3
Nombre de copier/coller : 0
Impression : 0

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Cancer Drug Delivery Systems Based on the Tumor Microenvironment , MATSUMURA , YASUHIRO*TARIN , DAVID
© LIVRES NUMÉRIQUES DIVERS 2020