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LIVRES NUMÉRIQUES
Analyzing T Cell Responses - FRANCESCO M. MARINCOLA - DIRK NAGORSEN

Analyzing T Cell Responses

Titre de l'éditeur : Analyzing T Cell Responses

FRANCESCO M. MARINCOLA
DIRK NAGORSEN

 
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EN SAVOIR PLUS Résumé

Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer vaccine strategy, a surrogate immunological end-point that correlates with clinical outcome needs to be defined, since it would facilitate the rapid comparison of these various formulations. Traditional immunological assays such as ELISA, proliferation and cytotoxicity assays can detect immune responses in vaccinated patients but are not quantitative. In contrast, novel assays such as enzyme-linked immunospot (ELISPOT) assay, intracellular cytokine assay and tetramer assay can quantitate the frequency of antigen-specific T cells. Of these, the ELISPOT assay has the 5 lowest detection limit with 1/10 peripheral blood mononuclear cells (PBMC) and has been determined to be one of the most useful assays to evaluate immune response to cancer vaccines (4). However, the IFN-? ELISPOT assay is not an exclusive measure of cytotoxic T-lymphocyte (CTL) activity as non-cytotoxic cells can also secrete IFN-?. Additionally, CTL with lytic activity do not always secrete IFN-? (5). A more relevant approach to assess functional activity of cytotoxic lymphocytes would be to measure the secretion of molecules that are associated with lytic activity. One of the major mechanisms of cell-mediated cytotoxicity involves exocytosis of cytoplasmic granules from the effector toward the target cell.

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Prix : 234,02 $
Catégorie :
Auteur :  FRANCESCO M. MARINCOLA
DIRK NAGORSEN
Titre : Analyzing T Cell Responses
Date de parution : janvier 2006
Éditeur : LIVRES NUMÉRIQUES DIVERS
Sujet : NUL DIVERS
ISBN : 9781402036231 (140203623X)
Référence Renaud-Bray : 2340384
No de produit : 2340384
Droits numériques
Format : PDF
Disponibilité : Canada, consultez la liste des pays autorisés.
Gestion des droits numériques : Adobe DRM
Entrepôt numérique : NUMILOG
Nombre d'appareils autorisés : 3
Nombre de copier/coller : 0
Impression : 0

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Analyzing T Cell Responses , MARINCOLA , FRANCESCO M.*NAGORSEN , DIRK
© LIVRES NUMÉRIQUES DIVERS 2006