LIVRES JEUNESSEBÉBÉJEUX, JOUETSPAPETERIECADEAUXDIVERTISSEMENT


Message Important
Le site sera temporairement en maintenance, pour une mise à jour. Ceci afin de mieux vous servir.
Heure de maintenance prévue : 10:30 pm

Important message
The site will be busy updating the store for you and will be back shortly.
Scheduled maintenance : 10:30 pm
LIVRES NUMÉRIQUES
Cystogenesis - CURIE AHN - JONG HOON PARK

Cystogenesis

Titre de l'éditeur : Cystogenesis

CURIE AHN
JONG HOON PARK

 
200,73 $
Feuilleter Feuilleter
Ajouter à ma liste de souhaits
EN SAVOIR PLUS Résumé

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.


Détails
Prix : 200,73 $
Catégorie :
Auteur :  CURIE AHN
JONG HOON PARK
Titre : Cystogenesis
Date de parution : octobre 2016
Éditeur : LIVRES NUMÉRIQUES DIVERS
Sujet : NUL DIVERS
ISBN : 9789811020414 (9811020418)
Référence Renaud-Bray : 2146978
No de produit : 2146978
Droits numériques
Format : PDF
Disponibilité : Canada, consultez la liste des pays autorisés.
Gestion des droits numériques : Adobe DRM
Entrepôt numérique : NUMILOG
Nombre d'appareils autorisés : 3

SUGGESTIONS
Suggestions
Une vie sans peur et sans regret BOMBARDIER, DENISE
25,99 $
Détresse et l'enchantement(La) 3e Ed. ROY, GABRIELLE
14,99 $
Détresse et l'enchantement(La) 3e Ed. ROY, GABRIELLE
14,99 $
Cystogenesis , AHN , CURIE*PARK , JONG HOON
© LIVRES NUMÉRIQUES DIVERS 2016