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Cystogenesis
Titre de l'éditeur : Cystogenesis
CURIE AHN
JONG HOON PARK
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EN SAVOIR PLUS
Résumé
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Détails
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Prix :
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132,46 $
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Catégorie :
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Auteur :
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CURIE AHN
JONG HOON PARK
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Titre :
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Cystogenesis
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Date de parution :
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décembre 2018
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Éditeur :
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LIVRES NUMÉRIQUES DIVERS
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Sujet :
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NUL DIVERS
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ISBN :
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9789811020414 (9811020418)
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Référence Renaud-Bray :
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2146978
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No de produit :
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2146978
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Droits numériques
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Format :
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PDF
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Disponibilité :
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Canada,
consultez la liste des pays autorisés.
Cystogenesis
De
AHN , CURIE*PARK , JONG HOON
ANDORRE
ÉMIRATS ARABES UNIS
ALBANIE
ARMÉNIE
ANTARCTIQUE
ARGENTINE
SAMOA AMÉRICAINES
AUTRICHE
AUSTRALIE
AZERBAÏDJAN
BOSNIE-HERZÉGOVINE
BARBADE
BELGIQUE
BURKINA FASO
BULGARIE
BAHREÏN
BURUNDI
BÉNIN
BERMUDES
BRUNÉI DARUSSALAM
BOLIVIE
BRÉSIL
BAHAMAS
BOUVET, ÎLE
BELIZE
Canada
CONGO, LA RÉPUBLIQUE DÉMOCRATIQUE DU
CONGO
SUISSE
CÔTE D'IVOIRE
COOK, ÎLES
CHILI
CAMEROUN
CHINE
COLOMBIE
COSTA RICA
CUBA
CAP-VERT
CHRISTMAS, ÎLE
CHYPRE
TCHÈQUE, RÉPUBLIQUE
ALLEMAGNE
DJIBOUTI
DANEMARK
DOMINIQUE
DOMINICAINE, RÉPUBLIQUE
ALGÉRIE
ÉQUATEUR
ESTONIE
ÉGYPTE
ESPAGNE
FINLANDE
FALKLAND, ÎLES (MALVINAS)
FÉROÉ, ÎLES
FRANCE
GABON
GRENADE
GÉORGIE
GUYANE FRANÇAISE
GIBRALTAR
GROENLAND
GUINÉE
GUADELOUPE
GUINÉE ÉQUATORIALE
GRÈCE
GUATEMALA
GUINÉE-BISSAU
GUYANA
HONG-KONG
HEARD, ÎLE ET MCDONALD, ÎLES
HONDURAS
CROATIE
HAÏTI
HONGRIE
INDONÉSIE
IRLANDE
ISRAËL
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Gestion des droits numériques :
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Adobe DRM
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Entrepôt numérique :
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NUMILOG
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Nombre d'appareils autorisés :
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3
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Nombre de copier/coller :
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0
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Impression :
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0
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Cystogenesis
,
AHN , CURIE*PARK , JONG HOON
©
LIVRES NUMÉRIQUES DIVERS
2018
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